Nos publications

@article{nokey,

title = {Multicentre Evaluation of Cepheid Xpert® Research-Use-Only Panel for Molecular Rapid Detection of Gastrointestinal Pathogens},

author = {Olivier Dauwalder, Jan Kehrmann, Stéphane Corvec, Maroussia Roelens, Tiphaine Roussel-Gaillard, Edoardo Bixio, Jan Buer, Elisa Baillemont, Martin Prodel, Valeria Cento},

url = {https://www.mdpi.com/2076-2607/14/9/2011},

doi = {10.3390/microorganisms14092011},

issn = {2076-2607},

year  = {2026},

date = {2026-09-10},

journal = {Microorganisms},

volume = {14},

number = {2011},

issue = {9},

abstract = {Rapid and accurate identification of enteric pathogens is essential for the management of acute infectious diarrhoeal diseases. Multiplex PCR panels have emerged as first-line screening tools to conventional stool culture by providing broad pathogen coverage and shorter turnaround times. This study evaluated the diagnostic performance of the Cepheid Xpert gastrointestinal (GI) research-use-only (RUO) panel in routine clinical practice across multiple European centres. A multicentre study was conducted in four hospitals across France, Germany and Italy. Stool specimens collected as part of routine care were tested using local standard-of-care (SoC) methods, including conventional stool culture, BDMax® Enteric Panels, or BioFire FilmArray® GI Panel, and subsequently analysed using the Cepheid Xpert GI RUO panel. A total of 11 bacterial, viral and parasitic enteropathogens were targeted. Discordant results underwent additional testing, and a consensus result based on a two-out-of-three agreement rule was used as the reference standard. Diagnostic performance metrics, agreement with SoC methods, microbiological findings and turnaround times were assessed. Of 508 samples, 115 (22.6%) were identified as positive for at least one pathogen according to the consensus result, including 12 samples with co-detection of more than one pathogen (10.4% of positive samples), resulting in a total of 128 pathogens detected. The most frequently detected pathogens were Campylobacter spp. (37 specimens), Norovirus (26 specimens), and Salmonella spp. (25 specimens). Compared with the consensus reference standard, Xpert achieved an overall sensitivity of 98% (95% CI: 94–100%), specificity of 100% (95% CI: 100–100%), positive predictive value of 95% (95% CI: 90–98%), and negative predictive value of 100% (95% CI: 100–100%). Sensitivity was ≥95% and specificity ≥99% for all evaluable targets. Agreement with routine diagnostic methods was high, with overall positive and negative percent agreements exceeding 90% and a Cohen's kappa coefficient of 0.91. Median analytical turnaround time was 1 h 18 min for Xpert, compared with 3 h for BDMax, 1 h 15 min for BioFire and 48 h for conventional stool culture. The Cepheid Xpert GI (RUO) panel provided highly accurate detection of enteric pathogens across heterogeneous European diagnostic settings and reduced turnaround time by more than 95% compared with conventional stool culture. A future IVD version of this test could provide rapid and accurate detection of enteric pathogens for potential routine management of patients with suspected acute infectious gastroenteritis.},

keywords = {biostatistics},

pubstate = {published},

tppubtype = {article}

}

@article{PERROT2025,

title = {Survival, Years of Life Lost and Attrition Rates in Multiple Myeloma Patients in France},

author = {Aurore Perrot and Fanny Raguideau and Helene Denis and Martin Prodel and Matthieu Javelot and Marie Pierres and Cyrille Touzeau},

url = {https://www.sciencedirect.com/science/article/pii/S2152265025000801},

doi = {https://doi.org/10.1016/j.clml.2025.03.004},

issn = {2152-2650},

year  = {2025},

date = {2025-01-01},

urldate = {2025-01-01},

journal = {Clinical Lymphoma Myeloma and Leukemia},

abstract = {Background 

In a context of strong evolution of multiple myeloma (MM) treatment paradigm, real-world data allow a better understandingthe patients' medical needs. 

Methods 

The present analyses from the MYLORD study were designed to provide recent data on MM patients: characteristics, overall survival (OS), years of life lost (YLL) and attrition rates, using the French National Health Insurance Database (SNDS). It is based on a cohort of 33,032 MM patients who initiated a frontline therapy from 2014 to 2021 in France and who were followed until 2021. 

Results 

The 5-year OS rate is estimated at 51.9% (95% CI: 51.2–52.6). This rate is 78.3% (95% CI: 77.1–79.5) for patients with frontline autologous stem cell transplant (L1T) and 43.6% (95% CI: 42.8–44.4) for those without transplant (L1NT). The excess of mortality in MM patients is revealed by 12.3 YLL versus the matched general population and is higher in L1T patients than those L1NT (17 vs. 11 years). The attrition rate is important in MM patients with 38% of patients who did not benefit from at least 2 lines of treatment and is higher in L1NT patients than those in L1T (41% vs. 29%). Also, the majority of L1NT patients did not receive a L2 because of death, whereas it is because of stay in line status for L1T patients. 

Conclusion 

These results emphasize the urgency to treat MM patients with the best and tailored treatment strategy available, for all MM patients beneficiating or not from a transplant in frontline therapy. Further studies will be needed to assess the impact of new therapeutic options in real life.},

keywords = {biostatistics, pathways},

pubstate = {published},

tppubtype = {article}

}

@article{laurent2019analyses,

title = {Analyses des séquences de traitements à partir du SNIIRAM: cas d’étude des incidents 2013 du VIH},

author = {Marie Laurent and Lucie Leotoing and Martin Prodel},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {Revue d'Épidémiologie et de Santé Publique},

volume = {67},

pages = {S177–S178},

publisher = {Elsevier},

keywords = {biostatistics, machine learning},

pubstate = {published},

tppubtype = {article}

}

@article{lawton2019cost,

title = {Cost-of-illness of inflammatory bowel disease patients treated with anti-tumour necrosis factor: A French large single-centre experience},

author = {Jean Lawton and Hamza Achit and Lieven Pouillon and Emmanuelle Boschetti and Béatrice Demore and Thierry Matton and Charlène Tournier and Martin Prodel and Laurent Peyrin-Biroulet and Francis Guillemin},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {United European Gastroenterology Journal},

volume = {7},

number = {7},

pages = {908–913},

publisher = {SAGE Publications Sage UK: London, England},

keywords = {biostatistics},

pubstate = {published},

tppubtype = {article}

}

@article{genreau2019pin35,

title = {Global annual costs of people living with HIV in France in 2013 from a national insurance claims database (Sniiram)},

author = {Marie Genreau and Martin Prodel and Lucie Léotoing and Laurent Finkielsztejn and Gaëlle Nachbaur and Laetitia Roustand and Jade Ghosn and Fabrice Bonnet},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {Value in Health},

volume = {22},

pages = {S645–S646},

publisher = {Elsevier},

keywords = {biostatistics},

pubstate = {published},

tppubtype = {article}

}

@article{bourgoin2015effects,

title = {Effects of moderate hyperbilirubinemia on nutritive swallowing and swallowing-breathing coordination in preterm lambs},

author = {Mélisande Bourgoin-Heck and Marie-Laure Specq and Nathalie Samson and Charlène Nadeau and Martin Prodel and François Corbin and Jean-Paul Praud},

year  = {2015},

date = {2015-01-01},

urldate = {2015-01-01},

journal = {Neonatology},

volume = {108},

number = {1},

pages = {42–48},

publisher = {S. Karger AG},

keywords = {biostatistics},

pubstate = {published},

tppubtype = {article}

}

@article{bourgoin2014sfp,

title = {Effet d’une hyperbilirubinémie sur la déglutition et la coordination déglutition-respiration chez l’agneau prématuré},

author = {Mélisande Bourgoin-Heck and ML Specq and N Samson and Martin Prodel and C Nadeau and François Corbin and JP Praud},

year  = {2014},

date = {2014-01-01},

urldate = {2014-01-01},

journal = {Archives de Pédiatrie},

volume = {21},

number = {5},

pages = {645},

publisher = {Elsevier},

keywords = {biostatistics},

pubstate = {published},

tppubtype = {article}

}